Mix woods of Aquilaria agallocha and Santalum album, Aegle marmelos root, Nelumbo nucifera receptacle, Tinospora sinensis stem juice, roots of Sida cordifolia and Chrysopogon zizanioides together and pour water to the mixture. Alpinia galanga induced apoptosis in MCF-7 cells, as determined by flow cytometry. Alpinia galanga. The rhizome has been shown to have weak antimalarial activity in mice. A significant effect of ginger extract on joint pain was demonstrated in the first period of treatment before crossover while no significant difference was observed in the study as a whole.131 A 12-week randomized open label study in patients with knee OA evaluated the safety and efficacy of diclofenac with a placebo, ginger with a placebo, and ginger with diclofenac. Pinostrobin, a flavonoid from this plant showed cytotoxic activity against human mammary carcinoma cells (Sukardiman et al., 2000). You'll find these and other characteristics below. Alpinia galanga extract; Alpinia galanga extract. The plant has been cultivated for the rhizomes in India, China, and Southeast Asia. Widespread contact dermatitis resembling erythema multiforme has been attributed to Alpinia galanga in a 54-year-old woman who applied slices of the plant in oil of Cinnamomum camphora (Lauraceae) to her back as a herbal remedy; patch tests were positive to the former and not the latter. [1]. It may represent a novel promising immunotherapeutic agent or a lead for cancer treatment (Gao et al., 2005). Fig. Willd. Three anthraquinone glycosides (pulmatin, chrysophanein and physcionin) isolated from Rheum palmatum roots exhibited moderate cytotoxic activity against HeLa epitheloid cells and inhibited the growth of BT-20 human breast carcinoma cells (Kubo et al., 1992). In humans studies, EnXtra® has been synergistic with caffeine. Alkaloids and quassinoids from Eurycoma longifolia, iridoids and lignans from Plumeria rubra showed cytotoxic activity to human breast, colon, fibrosarcoma, lung, melanoma, KB, KB-V1 cancer cell lines and in murine lymphocytic leukaemia (Kardono et al., 1990, 1991). Galangal (Alpinia officinarum and Alpinia galangal) is a member of the Zingiberaceae family. Andrographis paniculata also called sambiloto by native Indonesians has been intensively investigated for its anticarcinogenic activity. 2020 Oct 11;11(10):686. doi: 10.3390/insects11100686. There was moderate evidence suggesting that ginger was modestly efficacious and reasonably safe for treatment of OA.133 Another systematic review evaluated the safety and effectiveness of ginger in adults with OA with five randomized controlled trials. Please enable it to take advantage of the complete set of features! More studies explained that Allium extracts may have the ability to alter the transferring process of proteins such as f-actin, talin, and paxillin, which are important at the engulfment processes of phagocytosis.51 Compounds such as diallyl sulfide, S-allylmercaptocysteine, and ajoene are also reported to inhibit the nuclear transcription factor kappaB linked to the activation of psoriasis; these molecules can be isolated from Allium species.52 Isatis tinctoria (Brassicaceae) and Chelidonium majus are also reported to contain alkaloids including isaindigotone, tryptanthrin and chelerythrine, sanguinarine with anti 5-lipoxygenase activities. The extract of bark collected in the summer season has the highest activity (Jagetia and Baliga, 2004, 2005).  |  Add. 19 Antianaphylactic effects : Alpinia oxyphylla water extract suppressed immunoglobulin E-mediated anaphylactic reaction in … USA.gov. Phenylalanine arginine β-naphthylamide (PAβN) is an effective inhibitor of bacterial efflux pump systems. Copyright © 2020 Elsevier B.V. or its licensors or contributors. Its inflorescence is a short raceme of white flowers that are veined and shaded in dull red. Our results indicated that the crude A. galanga hexane extract had higher toxicity than the other crude extracts from the A. galanga. Although the mechanism is not fully understood, this compound inhibits activation of NF-κB and NF-κB-regulated gene expression. This suggested that both nonpolar … Add. Galangal rhizomes appear on the market as branched or simple rhizome fragments with wavy, reddish-brown annulations of the leaf bases that have an aromatic, spicy, and pungent odor and flavor. Galangal belongs to the ginger family. Ruttanaphan T, de Sousa G, Pengsook A, Pluempanupat W, Huditz HI, Bullangpoti V, Le Goff G. Insects. Research shows that galangal extract exerts an antimicrobial effect on several bacteria known for infecting foods, including staphylococcus, E. coli, listeria, salmonella and clostridium. Savka MA, Dailey L, Popova M, Mihaylova R, Merritt B, Masek M, Le P, Nor SR, Ahmad M, Hudson AO, Bankova V. Evid Based Complement Alternat Med. In this regard, 5-hydroxy-2-methyl-1,4-naphthaquinone (plumbagin), derived from the root of Plumbago zeylanica, has shown an inhibitory influence on R-plasmids from resistant E. coli. It has been licensed as a standardized herbal medicine in Indonesia for this indication and has proven the activity. 2014;79(2):145-9. 2020 May 30;11(6):336. doi: 10.3390/insects11060336. The analogues gave stronger activity than plumieride itself (Dobhal et al., 2004). EnXtra® is a clinically studied and standardized Alpinia galanga rhizome extract. It is a basic spice in the Indonesian national dish “nasi goreng,” a rice dish cooked with vegetables, meat, gravy, fruit, and mushrooms. In vitro (in cancer cells) and in vivo (in animal models), it suppressed carcinogenesis of the liver, kidney, colon, and breast (Okazaki et al., 2005; Kirana et al., 2003). ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. URL: https://www.sciencedirect.com/science/article/pii/B9780444537171016590, URL: https://www.sciencedirect.com/science/article/pii/B9780128110799000136, URL: https://www.sciencedirect.com/science/article/pii/B9780128138205000064, URL: https://www.sciencedirect.com/science/article/pii/B9780123985392000124, URL: https://www.sciencedirect.com/science/article/pii/S0378874116304779, URL: https://www.sciencedirect.com/science/article/pii/S2210803314000049, Meyler's Side Effects of Drugs (Sixteenth Edition), A. Parsaeimehr, ... R. Parra-Saldívar, in, The Microbiology of Skin, Soft Tissue, Bone and Joint Infections, Nutrients and Dietary Supplements for Osteoarthritis, Bioactive Food as Dietary Interventions for Arthritis and Related Inflammatory Diseases (Second Edition), Perspectives and Key Factors Affecting the Use of Herbal Extracts against Multidrug-Resistant Gram-Negative Bacteria, Ali Parsaeimehr, ... Amir Reza Jassbi, in, Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and Their Components, Plants used to treat diabetes in Sri Lankan Siddha Medicine – An ethnopharmacological review of historical and modern sources, Saravanan V. Sathasivampillai, ... Michael Heinrich, in, Jamu: Indonesian traditional herbal medicine towards rational phytopharmacological use, Chattopadhyay et al., 2004a,b; Karunagaran et al., 2005, Okazaki et al., 2005; Kirana et al., 2003, Agarwal et al., 2003; Sharma et al., 2005, Kirana et al., 2003; Manju and Nalini, 2005. 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